CBD oil has positively affected numerous individuals in treating their medical conditions, but that doesn’t mean that CBD oil use is risk-free. Although the side effects of CBD oil are typically very mild and subside quickly,, that doesn’t mean that CBD oil can’t produce some discomfort. In fact, most of the issues relating to CBD oil’s side effects stem from contaminants or poor-quality CBD. Apart from shoddy manufacturing, CBD oil side effects do exist in some cases.

Parkinson’s Disease

A study published in 1986 in the International Journal of Neuroscience detailed the effects of CBD oil in 5 patients with muscle tremors and other movement-related disorders. According to the research, “side effects of CBD were mild and included hypotension, dry mouth, psychomotor slowing, lightheadedness, and sedation.” 2 patients with symptoms of Parkinson’s Disease experienced increased hypokinesia and resting tremors when they exceeded CBD doses over 300 mg per day. Other research, however, has shown that CBD may reduce tremors in many individuals with PD, so the jury’s still out.


Another study on the effects of CBD on children with epilepsy found that 89% experienced fewer seizures. Not all children benefitted from CBD. Five patients in the study experienced a worsening of seizures and stopped taking the treatment altogether. Other side effects included sleepiness, fatigue, gastrointestinal issues, and irritability. Some research suggests that a low dose of CBD may provide considerable relief with minimal side effects.

Other Mild Side Effects

A 2017 scientific review noted that “the most commonly reported side effects [of CBD] were tiredness, diarrhea, and changes of appetite/weight” in the treatment of epilepsy and psychotic disorders. Researchers suggested that CBD has a “better side effect profile” than traditional medications for these medical conditions. With loosening restrictions on CBD, more studies can uncover other possible side effects so consumers know what dose, if any, they should take.


There’s some anecdotal evidence of people experiencing headaches after CBD use. While this is a rare occurrence, there may be some cause for concern. Inexperienced users that take large amounts of CBD oil may experience headaches. Headaches may also be caused by certain additives contaminants or poor quality CBD oil. CBD has been used to treat migraines, but too much of a bad CBD batch can make things worse.

Potentially Harmful Interactions

Before starting up a CBD regimen, users should consult with their physician on possibly harmful medication interactions. For example, a study found that short-term CBD exposure increased the permeability of the placental barrier in pregnant women. CBD has also been found to interact with enzymes in the liver and inhibit hepatic drug metabolism. Essentially, CBD can reduce the efficacy of certain prescription drugs including steroids, antihistamines, antibiotics, and more.

CBD oil side effects are very rare and mild. Generally, regular CBD consumers report feeling better after consuming CBD. Although it’s tempting to get swept up into the fervor over CBD, it’s crucial to understand the potential CBD oil side effects. CBD can affect everyone differently depending on genetic, metabolic, and lifestyle factors. Through trial-and-error, you can optimize your dose to avoid feeling any CBD oil side effects.

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